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Becoming Forgetful, Anxious, Allergic, or Too Heavy? Story at-a-glance Your microbiome is one of the primary factors that drive your genetic expression, turning genes on and off depending on which microbes are present A number of health conditions and chronic diseases have been linked to the makeup of your microbiome, including depression, obesity, type 1 and type 2 diabetes, Crohn’s disease, brain diseases, autism, and allergies Recent research also suggests your microbiome may determine your immune response to vaccines, and that wearing contact lenses alter your eyes’ microbiome making you more prone to eye infections